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A newly fabricated bio-electronic uric acid detecting device can be used for wearable sensors

Newdelhi:25/4/23:A new flexible bio-electronic uric acid detecting device has been fabricated that can be used for various applications such as wearable sensors and point-of-care diagnostics.

Uric acid is one of the most important antioxidants that maintain blood pressure stability and reduce oxidative stress in living beings. The usual range of uric acid in blood ranges from 0.14 to 0.4 mmol dm-3, and for urine, 1.5 to 4.5 mmol dm-3. However, the fluctuation of uric acid levels due to the lack of balancing between the production and excretion causes several diseases like hyperuricemia, which in turn may lead to gout disease, type 2 diabetes, increase risk of cardiovascular diseases, Lesch–Nyhan syndrome, hypertension, and renal disorders.

Researchers from the Institute of Advanced Study in Science and Technology (IASST), an autonomous institute of the Department of Science and Technology (DST), fabricated this device made up of reduced phosphorene quantum dots — a new class of zero-dimensional functional nanostructures with unique physicochemical and surface properties. The quantum dots show distinctive electrical performance in biomedical applications and so can be used in fabricating high-performance electrical biosensors.

The current-voltage and the impedance (opposition electron flow) responses for the fabricated device have been studied with increased uric acid concentration. With the increase in uric acid concentration, the current density increases and shows a maximum current of about 1.35 ×10-6 A.

The fabricated device shows reversibility in interaction with the uric acid, which repeatedly enables the use of the device for sensing experiments. It outperforms all currently available ones in terms of effectiveness and cost because it doesn’t need any enzymes.

The response of the fabricated device was investigated with real samples like human blood serum and artificial urine. The device so developed is simple, portable, cost-effective, and easy to fabricate for detecting uric acid with a limit of about 0.809 µM. This work, led by Prof. Neelotpal Sen Sarma and his Ph. D student Nasrin Sultana was recently published in the journal ACS Applied Electronic Materials.

About Editor in chief

Ashok Palit has completed his graduation from Upendranath College Soro, Balasore and post graduation from Utkal University in Odia Language and literture.. He has also carved out a niche for himself as a scribe of eminence after joining the profession in 1988. He is also an independent media production professional. He brings loads of experience to Advanced Media, Ashok Palit as a cineaste has been active in film criticism for over three decades. As a film society activist, he soared to eminence for his profound commitment to the art film appreciation and aesthetics of cinema. His mode of discourse is often erudite but always lucid and comprehensible marked by a perfect acumen so rare in the field. A film aesthete with an immense fond of critical sensibilities, he wrote about growth and development of odia cinema in New Indian Express, The Times of India, The Hindustan Times, The Asian Age and Screen. He has been working as an Editor for Cine Samaya from 2002-2004.. He had made solid contribution on cinema in many odia Dailies and weekly such as Samaj, Prajatantra, Dharatri, Samaya, Satabadi, and weekly Samaya.
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