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Efficacy of COVID vaccine may land between 50-100%:

New Delhi:22/9/20: The Indian Council of Medical Research (ICMR) said that the efficacy of the COVID-19 vaccine in India is likely to remain between 50 to 100 percent, however, they are trying for 100 percent efficiency.

“We are aiming for 100 percent efficacy but may land between 50 to 100 percent. However, it still would be an effective vaccine against the virus,” ICMR Director-General Dr. Balram Bhargava said while speaking to media during a press briefing of Ministry of Health and Family Welfare on Tuesday.

Bhargava added that as per the World Health Organisation (WHO), a vaccine having above 50 percent efficacy is acceptable for administration. “100 percent efficacy is not achieved in vaccines for respiratory viruses,” he said.

The Drugs Controller General of India released draft guidelines for Covid-19 vaccine on Monday. The 39-page document lists several safety protocols that companies have to follow, including developing adaptive trial designs.

As per the guidelines, the vaccine that will go for approval must elicit superior immune responses compared to no vaccination against Covid-19. An individual who gets the vaccine should be protected from re-infection for at least a year.

Besides, the regulatory approval for the vaccines will come through only if companies demonstrate 50 percent efficacy in the primary endpoint or more than 30 percent efficacy in the secondary endpoints. This means a vaccine has to either prevent or decrease the severity of the disease in at least 50 percent of people vaccinated.

“To ensure that a widely deployed Covid-19 vaccine is effective, the primary efficacy endpoint point estimate for a placebo-controlled efficacy trial should be at least 50 percent, and the statistical success criterion should be that the lower bound of the appropriately alpha-adjusted confidence interval around the primary efficacy endpoint point estimate is (greater than) 30 percent,” the guidelines stated.

Meanwhile, the regulatory body also clarified in the guidelines that persons who have been infected with the SARS-CoV-2 virus in the past should be included in vaccine testing, as long as they do not have acute Covid-19 or other acute infectious illnesses.

About Editor in chief

Ashok Palit has completed his graduation from Upendranath College Soro, Balasore and post graduation from Utkal University in Odia Language and literture.. He has also carved out a niche for himself as a scribe of eminence after joining the profession in 1988. He is also an independent media production professional. He brings loads of experience to Advanced Media, Ashok Palit as a cineaste has been active in film criticism for over three decades. As a film society activist, he soared to eminence for his profound commitment to the art film appreciation and aesthetics of cinema. His mode of discourse is often erudite but always lucid and comprehensible marked by a perfect acumen so rare in the field. A film aesthete with an immense fond of critical sensibilities, he wrote about growth and development of odia cinema in New Indian Express, The Times of India, The Hindustan Times, The Asian Age and Screen. He has been working as an Editor for Cine Samaya from 2002-2004.. He had made solid contribution on cinema in many odia Dailies and weekly such as Samaj, Prajatantra, Dharatri, Samaya, Satabadi, and weekly Samaya.

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